Table of Contents

The Two Page Version
 Origin of the Cells of the Immune System
 Antigens

Chapter 1: Innate Immunity
1.1 Nervous system
1.2 Clotting Factors
1.3 Recognition Receptors on Innate Cells
1.4 Consequences of Activating Local Innate Cells
1.5 Influx of Plasma
1.6 Influx of Cells
1.7 Link to Adaptive Immunity - The Dendritic Cell

Chapter 2: Antibodies and the Cells That Make Them
2.1 Antibody Structure
2.2.1 Fab Region of Antibodies
2.2.2 Fc Region of Antibodies
2.3 Antibody Diversity
2.4 Antibody Isotypes (Classes)
2.5  The Cells that Make Antibody - B cells
2.5.1 B Cell Development
2.5.2 B Cell Activation
2.5.3 T and B Cell Interaction
2.5.4  B Cell Differentiation into Plasma Cells
2.6  Antibody Secretion
2.7 Class Switch
2.8  B Memory Cells
2.9  Antigens and Antigen-Antibody Interaction
2.9.1 Antigens
2.9.2  Antigen-Antibody Interaction

Chapter  3: Complement
3.1 Complement Activity
3.2 Complement-Induced Vasodilation and Increased Vascular  Permeability
3.3 Chemotaxis
3.4 Opsonization
3.5  Membrane Attack Complex -MAC
3.6 They Fight Back
 
Chapter  4:  T Cells
Preamble
4.1  T Cells
4.2  T Cell Development
4.3 Th cell Activation
4.4 Antigen Presenting Cells (APC)
4.5  T Cell Help -Th Cells
4.6  T Helper Cell Subsets
4.7  CD8+ T Cytotoxic Cells
4.8 Cytotoxic T Lymphocyte Activity

Chapter 5: Effector Cells of the Immune System
5.1 Monocytes and Macrophages
5.2  Natural Killer Cells
5.3  Neutrophils
5.4  Eosinophils
5.5  Mast Cells
5.6  Basophils

Chapter 6: Cytokines
6.1.1  Interleukin 1 (IL-1)
6.1.2  Interleukin 2 (IL-2)
6.1.3  Interleukin 4 (IL-4)
6.1.4  Interleukin 5 (IL-5)
6.1.5  Interleukin 6 (IL-6)
6.1.6  Interleukin 8 (IL-8)
6.1.7  Interleukin 10 (IL-10)
6.1.8  Interleukin 12 (IL-12)
6.2  Interferon Gamma (IFN-g)
6.3  Tumor Necrosis Factor Alpha (TNFa)
6.4  Transforming Growth Factor Beta (TGFb)

Chapter 7: Transplantation and Major Histocompatibility Complex
7.1 Preamble
7.2  Class I MHC
7.3  Class II MHC
7.4  Indirect Presentation
7.5  Clinical Note: HLA Typing

Chapter 8: Hypersensitivity
8.1 Type I Hypersensitivity: Allergy and Asthma
8.1.1  Anaphylaxis
8.2 Type II Hypersensitivity: Antibody Mediated Cell Lysis
8.3 Type III Hypersensitivity: Immune Complex Disease
8.4 Type IV Hypersensitivity: Delayed Type Hypersensitivity

Chapter 9: Autoimmunity
9.1 Release of Sequestered Antigen
9.2 Molecular (Antigenic Mimicry)
9.3. Polyclonal B Cell Activation
9.4 Common Autoimmune Diseases
9.4.1 Diabetes
9.4.2 Systemic Lupus Erythematosus (SLE)
9.4.3 Rheumatoid Arthritis (RA)
9.4.4. Multiple Sclerosis (MS)
9.4.5 Graves Disease and Autoimmune Thyroiditis
9.4.6 Myasthenia Gravis

Chapter 10: Immune Deficiency
10.1 Antibody Deficiencies
10.1.1  IgA Deficiency
10.1.2  X-linked Agammaglobulinemia (XLA)
10.1.3  Common Variable Immunodeficiency (CVI)
10.2 Deficiencies in Cell Mediated Immunity.
10.2.1  SCID

Chapter 11: Host Defence
11.1 Extracellular Bacterial Pathogens
11.2 Intracellular Bacterial Pathogens
11.3 Viral Infections
11.4  Extracellular Protozoa
11.5 Intracellular Protozoa
11.6 Helminth Parasites

Chapter 12:  Vaccines
12.1 Whole Organism Vaccines
12.1.1  Live Vaccines
12.1.2  Killed Vaccines
12.2 Sub-unit Vaccines
12.2.1  Isolated Protein Vaccines
12.2.2  Vector Vaccines
12.2.3  Polysaccharide Vaccines
12.3 Passive Immunity

Appendices

Appendix 1: Lymphoid Tissue (diagram)
Appendix 2: Complement (diagram)
Appendix 3: Clinical Note - Normal Antibody Levels
Appendix 4: Clinical Note – Immunization
Appendix 5: Clinical Note – IgE and Eosinophil Response to Parasite Infection
Appendix 6: Clinical Note – HLA Typing
Appendix 7: Clinical Note – B Cell Malignancies